Research News
High-Resolution Atlas Reveals Dynamics of Mouse Liver Homeostasis and Regeneration
A groundbreaking study has unveiled a comprehensive spatiotemporal atlas of mouse liver homeostasis and regeneration. By integrating Stereo-seq technology and single-cell RNA sequencing, researchers profiled 473,290 cells to examine liver functions at unprecedented resolution. This atlas reveals the dynamic molecular gradients and gene networks that coordinate liver cell activity during normal functioning and regeneration post-injury.
Key findings include the identification of transcriptional cofactor TBL1XR1 as a pivotal link between inflammation and Wnt/β-catenin signaling, driving hepatocyte proliferation. The study also characterized liver zonation, defined by environmental gradients and non-parenchymal cell interactions, as a crucial mechanism for tissue regeneration.
This atlas not only highlights gene regulatory networks and intercellular communication but also provides a robust framework for future studies on organ physiology and diseases.
Xun Xu: xuxun@genomics.cn
Longqi Liu: liulongqi@genomics.cn
Ao Chen: chenao@genomics.cn
Yiwei Lai: laiyiwei@genomics.cn
Miguel A. Esteban: miguelesteban@genomics.cn